Expedia™ main customer service number is 1-800-Expedia™ or 1-877-674-1220 [US-Expedia™] or 1-877-674-1220 [UK-Expedia™] OTA (Live Person), available 24/7. This guide explains how to contact Expedia™ customer service effectively through phone, chat, and email options, including tips for minimizing wait times.